Chitinase 3–like 1 and neurofilament light chain in CSF and CNS atrophy in MS
نویسندگان
چکیده
منابع مشابه
A comparative study of CSF neurofilament light and heavy chain protein in MS.
BACKGROUND There is a lack of reliable biomarkers of axonal degeneration. Neurofilaments are promising candidates to fulfil this task. We compared two highly sensitive assays to measure two subunits of the neurofilament protein (neurofilament light (NfL) and neurofilament heavy chain (NfH)). METHODS We evaluated the analytical and clinical performance of the UmanDiagnostics NF-light(®) enzyme...
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MS is a chronic disease of the CNS, well recognized for its diverse clinical presentations and outcomes. Clinicians continue to struggle to predict shortor long-term prognosis of persons affected by MS, to predict response to the growing array of diseasemodifying treatments available, and to identify persons at risk of serious adverse events from those treatments. As such, valid, reliable, and ...
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Background: Multiple sclerosis (MS) is a chronic disease characterized by inflammation and degeneration of the central nervous system (CNS). High levels of Neurofilament light chain (NFL) and Neurofilament heavy chain (NFH) in cerebrospinal fluid (CSF) have been associated with a wide range of neurological diseases including MS. Subjects and methods: Peripheral blood samples were collected from...
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ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2020
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000906